Fitness Conferred by BCR-ABL Kinase Domain Mutations Determines the Risk of Pre-Existing Resistance in Chronic Myeloid Leukemia Kevin Leder1., Jasmine Foo2., Brian Skaggs3, Mercedes Gorre4, Charles L. Sawyers5, Franziska

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SEPTEMBER 2012 NEWSLETTERJUST SAYING------Leukemia: Affects 1 in 1,200 / Funding: $277 million Muscular Dystrophy: Affects 1 in 100,000 / Funding: $162 million Pediatric AIDS: Affects 1 inFunding: $394

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Leukemia, 1263–1274 & 2013 Macmillan Publishers Limited All rights reservedwww.nature.com/leu ORIGINAL ARTICLE

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C ngratulations TO The LEUKEMIA & LYMPHOMA SOCIETY’S 2015 National Man & Woman of The Year Winners national RUNNERS UP National Man of the Year

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Research A Robust Error Model for iTRAQ Quantification Reveals Divergent Signaling between Oncogenic FLT3 Mutants in Acute Myeloid Leukemia*□

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{ } PROUDLY PRESENTS A BENEFIT FOR THE LEUKEMIA & LYMPHOMA SOCIETY

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ASTELLAS ANNOUNCES PRELIMINARY PHASE 1/2 SAFETY, TOLERABILITY AND EFFICACY DATA FOR ASP2215 IN PATIENTS WITH RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA (AML)

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FLUORESCENCE PROPERTIES OF QUERCETIN IN HUMAN LEUKEMIA JURKAT T-CELLS I. BARAN1,*, C. GANEA1, I. URSU2, V. BARAN2,3, O. CALINESCU1, A. IFTIME 1, R. UNGUREANU1, I.T. TOFOLEAN1 1

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Leukemia, 1698–1706 & 2008 Macmillan Publishers Limited All rights reserved $32.00 www.nature.com/leu ORIGINAL ARTICLE PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR

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